| Title | Value | ||||
|---|---|---|---|---|---|
| Polysaccharide | PS - WNP | ||||
| Source Name | Polygonatum sibiricum | ||||
| Weight | 76kDa | ||||
| Main Glycosidic Bond(s) | |||||
| Main Chain | The main chain is composed of (1→6)-galactopyranosyl (Residue - A) and (1→2,6)-di-galactopyranosyl (Residue - B). The terminal is (1→) mannopyranosyl (Residue - C). Residue - C is connected to the O-2 position of Residue - B. | ||||
| Side Chain | No relevant information could be found in the literature. | ||||
| NMR Information | unknown | ||||
| Monosaccharide |
|
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| Physiological Functions | It has a protective effect on Aβ₂₅₋₃₅-induced neurotoxicity in PC12 cells. It can inhibit apoptosis, regulate the ratio of Bcl-2/Bax, improve mitochondrial function, inhibit the release of cytochrome c and the activation of caspase-3. The mechanism is related to the activation of the PI3K/Akt signaling pathway. | ||||
| Intestinal Microbiota Regulation | unknown | ||||
| Related Diseases (based on ICD-11) | |||||
| Correlation map | Click to view | ||||
| DOI | 10.1016/j.carbpol.2014.10.034 |
Data Source Statement:
The data included in the DoLPHiN database is sourced exclusively from peer-reviewed original publications and presented after normalization.
The data included in the DoLPHiN database is sourced exclusively from peer-reviewed original publications and presented after normalization.